What is HipSci?

HipSci brings  together diverse constituents in genomics, proteomics, cell biology and clinical genetics to create a UK national iPS cell resource and use it to carry out cellular genetic studies.

Between 2013 and 2016 we aim to generate iPS cells from over 500  healthy individuals 500 individuals with genetic disease. We will then use these cells to discover how genomic variation impacts on cellular phenotype and identify new disease mechanisms.

Strong links with NHS investigators will ensure that studies on the disease-associated cell lines will be linked to extensive clinical information. Further key features of the project are an open access model of data sharing; engagement of the wider clinical genetics community in selecting patient samples; and provision of dedicated laboratory space for collaborative cell phenotyping and differentiation.

Recent project Announcements

Thursday, March 20, 2014

We are seeking clinicians (or scientists with access to relevant patient cases) to provide samples from patients with inherited genetic diseases for the disease component of the HipSci project. We request that samples are provided in groups of between 10 and 50 with related phenotypes, and that all samples already have the genetic defect identified (the aim is to support gene analysis rather than gene discovery), with typically multiple cases with defects in the same gene. We encourage clinicians/scientists with only small numbers of samples to form larger groups with others who can contribute similar cases.

If you wish to submit a proposal or have any questions please email hipsci-proposal@ebi.ac.uk
Full Details can be found on the iPS cells for Rare disease cases: call for proposals page and in the Proposal PDF

 

Tuesday, November 6, 2012

The Wellcome Trust and Medical Research Council (MRC) today announced a £12.75 million initiative to create a catalogue of high-quality adult stem cells, so-called induced pluripotent stem cells (iPS cells). The initiative will provide a knowledge-base to underpin the use of such cells in studying the effects of our genes on health and disease and lay the foundations to create a new iPS cell bank, providing a world-class resource for UK researchers.