The Human Induced Pluripotent Stem Cells Initiative (HipSci) is generating a large, high-quality reference panel of human iPSC lines for the research community.
HipSci stands apart from other iPSC projects in a number of respects:
- Magnitude – HipSci is systematically generating iPSCs from hundreds of donors using a standardised experimental pipeline.
- Cell line availability – HipSci’s cell lines are produced as a global iPSC resource. The cell lines are readily available from two cell banks (ECACC and EBiSC), for use by the wider research community.
- Cohorts – HipSci’s reference panel comprises hundreds of cell lines from phenotypically healthy donors, plus several cohorts of donors with inherited genetic diseases.
- The data – – Each line generated is extensively characterised. Assays include genotyping by array, expression array, methylation array, RNA-seq, Exome-seq, proteomics mass spectrometry, and high content cellular phenotyping.