The Human Induced Pluripotent Stem Cells Initiative (HipSci) is generating a large, high-quality reference panel of human IPSC lines.
HipSci stands apart from other IPSC projects in a number or respects:
Reprogramming of somatic human cells to a pluripotent state was first reported in 2008. In the original study, pluripotency was induced by ectopic expression of four specific transcription factors (OCT4, SOX2, KLF4, and MYC; also known as the Yamanaka factors), which trigger widespread changes in the epigenomes and transcriptional programs of the target cells and ultimately permanently reset their cellular state. Such cells are called induced pluripotent stem cells (iPSC).