Common genetic variation drives molecular heterogeneity in human iPSCs

The first major analysis of the HipSci cell line data is now availiable as a pre-print in BioRxiv

Common genetic variation drives molecular heterogeneity in human iPSCs
doi: http://dx.doi.org/10.1101/055160

Here, we describe the systematic generation, genotyping and phenotyping of 522 open access human iPSCs derived from 189 healthy male and female individuals.

Our study provides a comprehensive picture of the major sources of genetic and phenotypic variation in iPSCs and establishes their suitability for use in genetic studies of complex human traits and cancer.