The HipSci project is generating IPS cell lines from cohorts of patients with inherited genetic diseases. IPSC technology provides opportunity for modelling human genetic diseases in the culture dish, for developing therapeutic agents and for screening of potential drugs. Cell lines reprogrammed from the somatic cells of disease-carrying tissue donors can be differentiated into the disease-relevant tissues, which are not otherwise easily obtained from patients.

The HipSci collection of cell lines also includes a large number from phenotypically ‘normal’ donors, with no diagnosed genetic disease. Cell lines from phenotypically normal donors allows the study of how common genetic variations affect the cellular phenotypes.

Click on these links for more information on our disease cohorts