This request finished in June 2014. The HipSci project has finished recruiting samples.
The Human Induced Pluripotent Stem Cell initiative (HipSci), funded by the Wellcome Trust and the MRC, aims to generate iPS cells from healthy volunteers and patients with genetic disease. The project collaborators aim to generate over a thousand iPS cell lines, on which they will conduct extensive genetic analysis, and characterise how the cells respond to specific external stimuli.
The resulting cell collection and data-set will be the UK’s most comprehensive resource for investigating how genetic variation impacts on cell behaviour and how diseases linked to a specific genetic defect can result in a broad spectrum of clinical abnormalities. The project is led by King’s College London and the Wellcome Trust Sanger Institute. Further information is available at www.hipsci.org.
We are seeking clinicians (or scientists with access to relevant patient cases) to provide samples from patients with inherited genetic diseases for the disease component of the HipSci project. We request that samples are provided in groups of between 10 and 50 with related phenotypes, and that all samples already have the genetic defect identified (the aim is to support gene analysis rather than gene discovery), with typically multiple cases with defects in the same gene. We encourage clinicians/scientists with only small numbers of samples to form larger groups with others who can contribute similar cases.
Sample providers will receive back the iPSC produced to allow them to work with their cell lines, but the lines will also be available via a stem cell bank under an MTA to others for research purposes, either in academia or industry. We are in the process of obtaining overarching ethics permission for the genetic disease component of the study, so that contributing clinicians/scientists will only need to provide Site Specific Information for their samples.